Proceedings of the 1st Symposium of the Japanese Society for Ultrastructural Cutaneous Biology, Tokyo, 24-25 November 1999

Edited by

H. Suzuki, Department of Dermatology, Surugadai Nihon University Hospital, 1-8-13 Kanda- urugadai, Chioyoda-ku, Tokyo 101-8309, Japan T. Ono, Department of Dermatology, Kumamoto University School of Medicine, 1-1-1 Honjyo, Kumamoto 860-8556, Japan

Included in series International Congress, 1187

Description

The ICS series is proud to publish the proceedings of the 1st Symposium of the Japanese Society for Ultrastructural Cutaneous Biology, which will make a significant contribution to advances in the dermatological field.

Dr. Friedrich Merkel first identified the Merkel cells, which he called Tastzellen (touch cells) in 1875. However, it was not until the 1960s that the existence of Merkel cells in the human skin was confirmed by Dr. Cauna using electron microscopy.

1902 saw the discovery of the Haarscheiben (hair discs) by Dr. Felix Pinkus who reported that they are many Merkel cells beneath the epidermis of the disc. Today, the Merkel cell-neurite complex in the hair disc is regarded as a slow-adapting type I mechanoreceptor unit.

Since 1978, when Drs. Tang and Toker reported the concept of Merkel cell carcinoma, many cases have been identified worldwide. Neurobiology, neuropeptides and interaction between cutaneous innervation and the cells are now important topics in the dermatological field.

This volume brings together research on new developments in Merkel cells, Merkel cell carcinoma and neurobiology of the skin. The proceedings comprise the following sections:

—      Morphological aspects of Merkel cells in skin and oral mucosa

—      Physiological aspects of Merkel cells, as mechanoreceptors

—      Merkel cells in hair discs and hair follicles

—      Merkel cell hyperplasia and Merkel cell carcinoma

—      Neurobiology of the skin

It intends to improve understanding of the origin and nature of Merkel cells and related pathophysiological processes in the skin.

Audience

Perfect for dermatologists and neurobiologists of the skin

Contents

Morphological aspects of Merkel cells in skin and oral mucosa. Morphology and distribution of Merkel cells in some vertebrates (K. Toyoshima et al.). Morphological and developmental characteristics of oral mucosal Merkel cells (T. Tachibana, T. Nawa). Developmental origin of Merkel cells in birds (M. Grim, D. Halata). Topography of nerve terminals in Merkel nerve endings in mammals (Z. Halata, K.I. Baumann). Ultrastructure of the Merkel cells and their dependency on the nerve endings (K. Kurosumi). Merkel cell as a paraneuron (T. Fujita, S. Yoshie).

Physiological aspects of Merkel cells as mechanoreceptors. Calcium inflow of single Merkel cell in response to direct mechanical stimulation (M. Tazaki et al.). Calcium influx and calcium induced calcium release in mechanically stimulated Merkel cells of rat sinus hair type I mechanoreceptors (K.I. Baumann et al.). Merkel cells, possible mechanoreceptors (H. Ogawa).

Merkel cells in hair discs and hair follicles. Human haarscheiben: development, distribution and keratinocyte differentation (I. Moll). Postnatal morphogenesis and proliferative activity of epidermis in hair discs (H. Suzuki et al.). Follicular Merkel cells in different body sites of mice, guinea pigs and rats (Y. Narisawa et al.). Characteristics of Merkel cells in hair follicles in the facial skin (S. Uchigasaki et al.).

Merkel cell hyperplasia and Merkel cell carcinoma. Merkel cell hyperplasia in human skin tumors - potential biological significance and clues to diagnosis in dermatopathology (W. Hartschuh, E. Weihe, T. Schulz). Merkel cell carcinoma in Japan (T. Ono, K. Kayashima, K. Maruo). Clinical and histopathological diversity of Merkel cell carcinoma (K-I. Kayashima, T. Ono). Merkel cell carcinoma associated with bowenoid actinic keratosis (T. Muramatsu et al.). Immunohistochemical analysis of neuroendocrine carcinomas (Y. Takeuchi et al.). Ganglioside expression in Merkel cell carcinoma (M. Muto et al.). Merkel cell carcinoma with spontaneous regression (K. Maruo, K. Kayashima, T. Ono). Merkel cell carcinoma: an immunohistochemical and ultrastructural study (M. Kagoura et al.). Immunohistochemical and ultrastructural study of Merkel cell carcinoma of the thigh (T. Ochiai et al.).

Neurobiology of the skin. Keratinocyte nerve growth factor: more than just a neurotrophin (C. Pinceli, A. Marconi). Low-energy helium-neon laser irradiation stimulates basic fibroblast growth factor release from cultured human dermal fibroblasts (Y.-H. Kao, H.-S. Yu). Regulation of epidermal Langerhans cells by calcitonin gene-related peptide (J. Hosoi et al.). The production of the neurotrophic factors by epidermal Langerhans cells (H. Torii, K. Tamaki, R.D. Granstein). The alterations of cutaneous nervous system with cyclosporin A treatment in atopic dermatitis (M. Morohashi, M. Toyoda). New insights into the participation of cutaneous neurologic factors in photoaging processes (M. Toyoda et al.). Differences of skin reactions in adult and neonatal mice induced by substance P (N. Suzuki et al.). Anxiety and delayed adverse reactions to iodinated contrast media used in radiological examinations (Y. Mitsuhashi et al.). Index of authors. Keyword index.

Bibliographic & ordering Information

Hardbound, 400 pages, publication date: JUN-2000

ISBN-13: 978-0-444-50221-6

ISBN-10: 0-444-50221-1

Imprint: EXCERPTA MEDICA

Price: Order form

GBP 95.50

EUR 143

USD 143

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